Uluhlu lwevacuum oluqhelekileyo lwesomisi esifunxayo siqhelekile phakathi kwe-10 Pa kunye ne-1000 Pa, ngexabiso elithile eliphenjelelwa ziipropati zemathiriyeli kunye nokucubungula ubuchwepheshe. Olu luhlu lwe-vacuum lunenzuzo ekukhawuleziseni izinga le-sublimation kunye nokuphucula ukusebenza kakuhle kokumisa.
Inqanaba le-vacuum ye-vacuum freeze dryer libhekiselele kwinqanaba apho uxinzelelo lwegesi lwangaphakathi lungaphantsi kunoxinzelelo lwe-atmospheric yangaphandle. Le parameter ibalulekile ekusebenzeni okuqhelekileyo kwesixhobo kunye nomphumo wokomisa. Nangona kunjalo, akukho xabiso elifanayo kunye nesigxina kwinqanaba eliqhelekileyo le-vacuum ye-freeze dryer, njengoko ichaphazeleka ngezinto ezahlukeneyo, kubandakanywa uhlobo, iinkcukacha, ukusetyenziswa, kunye neemeko zokusebenza kwezixhobo.
